Evaluation of Mild Cognitive Impairment Subtypes in Parkinson’s Disease
Identifieur interne : 000588 ( Main/Exploration ); précédent : 000587; suivant : 000589Evaluation of Mild Cognitive Impairment Subtypes in Parkinson’s Disease
Auteurs : Brenna A. Cholerton [États-Unis] ; Cyrus P. Zabetian [États-Unis] ; Jia Y. Wan [États-Unis] ; Thomas J. Montine [États-Unis] ; Joseph F. Quinn [États-Unis] ; Ignacio F. Mata [États-Unis] ; Kathryn A. Chung [États-Unis] ; Amie Peterson [États-Unis] ; Alberto J. Espay [États-Unis] ; Fredy J. Revilla [États-Unis] ; Johnna Devoto [États-Unis] ; G. Stennis Watson [États-Unis] ; Shu-Ching Hu [États-Unis] ; James B. Leverenz [États-Unis] ; Karen L. Edwards [États-Unis]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2014.
English descriptors
- KwdEn :
- MESH :
- complications : Parkinson Disease.
- diagnosis : Mild Cognitive Impairment.
- etiology : Mild Cognitive Impairment.
- Adult, Aged, Aged, 80 and over, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Principal Component Analysis.
Abstract
Mild cognitive impairment in Parkinson’s disease (PD-MCI) is common and increases the risk for dementia. Establishing distinct PD-MCI cognitive subtypes could be valuable for eventually predicting those most likely to convert to dementia. To date, however, the study of PD-MCI subtypes has not yielded consistent results among cohorts.
To determine whether there are distinct cognitive subtypes among participants diagnosed with PD-MCI in the Pacific Northwest Udall Center Clinical Consortium.
We cognitively subtyped 95 patients with PD-MCI using the Movement Disorders Society Task Force diagnostic guidelines. Psychometric test scores were then subjected to principle components factor analysis to determine whether similar cognitive subgroups could be identified using statistical methodology.
Multiple-domain PD-MCI was diagnosed in 95% of the sample, and a range of cognitive impairments were noted. Factor analysis yielded seven factors, and demonstrated overlap of phonemic verbal fluency on two factors, as well as the loading of verbal fluency on the same factor as a visuospatial measure; however, these factors did not partition the sample into distinct cognitive subtypes.
Separation of cognitive subtypes based on the current PD-MCI criteria, or via statistical methods, may not provide sufficient information to describe distinct PD groups. Future efforts to validate the PD-MCI criteria and identify combinations of genetic or other risk factors for cognitive impairment are warranted.
Url:
DOI: 10.1002/mds.25875
PubMed: 24710804
PubMed Central: 4013249
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000392
- to stream Pmc, to step Curation: 000392
- to stream Pmc, to step Checkpoint: 000036
- to stream PubMed, to step Corpus: 000545
- to stream PubMed, to step Curation: 000545
- to stream PubMed, to step Checkpoint: 000603
- to stream Ncbi, to step Merge: 003F54
- to stream Ncbi, to step Curation: 003F54
- to stream Ncbi, to step Checkpoint: 003F54
- to stream Main, to step Merge: 000588
- to stream Main, to step Curation: 000588
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Evaluation of Mild Cognitive Impairment Subtypes in Parkinson’s Disease</title>
<author><name sortKey="Cholerton, Brenna A" sort="Cholerton, Brenna A" uniqKey="Cholerton B" first="Brenna A." last="Cholerton">Brenna A. Cholerton</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Geriatric Research, Education, & Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Geriatric Research, Education, & Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A4">Department of Psychiatry & Behavioral Science, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry & Behavioral Science, Seattle, WA</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zabetian, Cyrus P" sort="Zabetian, Cyrus P" uniqKey="Zabetian C" first="Cyrus P." last="Zabetian">Cyrus P. Zabetian</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Geriatric Research, Education, & Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Geriatric Research, Education, & Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A2">Parkinson’s Disease Research, Education, & Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Parkinson’s Disease Research, Education, & Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A5">Department of Neurology, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Seattle, WA</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wan, Jia Y" sort="Wan, Jia Y" uniqKey="Wan J" first="Jia Y." last="Wan">Jia Y. Wan</name>
<affiliation wicri:level="2"><nlm:aff id="A6">Department of Epidemiology, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, Seattle, WA</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Montine, Thomas J" sort="Montine, Thomas J" uniqKey="Montine T" first="Thomas J." last="Montine">Thomas J. Montine</name>
<affiliation wicri:level="2"><nlm:aff id="A7">Department of Pathology University of Washington School of Medicine, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology University of Washington School of Medicine, Seattle, WA</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Quinn, Joseph F" sort="Quinn, Joseph F" uniqKey="Quinn J" first="Joseph F." last="Quinn">Joseph F. Quinn</name>
<affiliation wicri:level="2"><nlm:aff id="A8">Portland Veterans Affairs Medical Center, Portland, OR, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Portland Veterans Affairs Medical Center, Portland, OR</wicri:regionArea>
<placeName><region type="state">Oregon</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A9">Department of Neurology, Oregon Health and Science University, Portland, OR, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Oregon Health and Science University, Portland, OR</wicri:regionArea>
<placeName><region type="state">Oregon</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mata, Ignacio F" sort="Mata, Ignacio F" uniqKey="Mata I" first="Ignacio F." last="Mata">Ignacio F. Mata</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Geriatric Research, Education, & Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Geriatric Research, Education, & Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chung, Kathryn A" sort="Chung, Kathryn A" uniqKey="Chung K" first="Kathryn A." last="Chung">Kathryn A. Chung</name>
<affiliation wicri:level="2"><nlm:aff id="A8">Portland Veterans Affairs Medical Center, Portland, OR, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Portland Veterans Affairs Medical Center, Portland, OR</wicri:regionArea>
<placeName><region type="state">Oregon</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A9">Department of Neurology, Oregon Health and Science University, Portland, OR, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Oregon Health and Science University, Portland, OR</wicri:regionArea>
<placeName><region type="state">Oregon</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Peterson, Amie" sort="Peterson, Amie" uniqKey="Peterson A" first="Amie" last="Peterson">Amie Peterson</name>
<affiliation wicri:level="2"><nlm:aff id="A8">Portland Veterans Affairs Medical Center, Portland, OR, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Portland Veterans Affairs Medical Center, Portland, OR</wicri:regionArea>
<placeName><region type="state">Oregon</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A9">Department of Neurology, Oregon Health and Science University, Portland, OR, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Oregon Health and Science University, Portland, OR</wicri:regionArea>
<placeName><region type="state">Oregon</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Espay, Alberto J" sort="Espay, Alberto J" uniqKey="Espay A" first="Alberto J." last="Espay">Alberto J. Espay</name>
<affiliation wicri:level="2"><nlm:aff id="A10">Department of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, OH, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, OH</wicri:regionArea>
<placeName><region type="state">Ohio</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Revilla, Fredy J" sort="Revilla, Fredy J" uniqKey="Revilla F" first="Fredy J." last="Revilla">Fredy J. Revilla</name>
<affiliation wicri:level="2"><nlm:aff id="A10">Department of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, OH, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, OH</wicri:regionArea>
<placeName><region type="state">Ohio</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A11">Cincinnati Veteran Affairs Medical Center, Cincinnati, OH, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Cincinnati Veteran Affairs Medical Center, Cincinnati, OH</wicri:regionArea>
<placeName><region type="state">Ohio</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Devoto, Johnna" sort="Devoto, Johnna" uniqKey="Devoto J" first="Johnna" last="Devoto">Johnna Devoto</name>
<affiliation wicri:level="2"><nlm:aff id="A10">Department of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, OH, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, OH</wicri:regionArea>
<placeName><region type="state">Ohio</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Watson, G Stennis" sort="Watson, G Stennis" uniqKey="Watson G" first="G. Stennis" last="Watson">G. Stennis Watson</name>
<affiliation wicri:level="2"><nlm:aff id="A4">Department of Psychiatry & Behavioral Science, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry & Behavioral Science, Seattle, WA</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hu, Shu Ching" sort="Hu, Shu Ching" uniqKey="Hu S" first="Shu-Ching" last="Hu">Shu-Ching Hu</name>
<affiliation wicri:level="2"><nlm:aff id="A5">Department of Neurology, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Seattle, WA</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Leverenz, James B" sort="Leverenz, James B" uniqKey="Leverenz J" first="James B." last="Leverenz">James B. Leverenz</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Geriatric Research, Education, & Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Geriatric Research, Education, & Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A2">Parkinson’s Disease Research, Education, & Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Parkinson’s Disease Research, Education, & Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A3">Mental Illness Research, Education, & Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Mental Illness Research, Education, & Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A4">Department of Psychiatry & Behavioral Science, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry & Behavioral Science, Seattle, WA</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A5">Department of Neurology, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Seattle, WA</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Edwards, Karen L" sort="Edwards, Karen L" uniqKey="Edwards K" first="Karen L." last="Edwards">Karen L. Edwards</name>
<affiliation wicri:level="2"><nlm:aff id="A6">Department of Epidemiology, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, Seattle, WA</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">24710804</idno>
<idno type="pmc">4013249</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013249</idno>
<idno type="RBID">PMC:4013249</idno>
<idno type="doi">10.1002/mds.25875</idno>
<date when="2014">2014</date>
<idno type="wicri:Area/Pmc/Corpus">000392</idno>
<idno type="wicri:Area/Pmc/Curation">000392</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000036</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="wicri:Area/PubMed/Corpus">000545</idno>
<idno type="wicri:Area/PubMed/Curation">000545</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000603</idno>
<idno type="wicri:Area/Ncbi/Merge">003F54</idno>
<idno type="wicri:Area/Ncbi/Curation">003F54</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">003F54</idno>
<idno type="wicri:doubleKey">0885-3185:2014:Cholerton B:evaluation:of:mild</idno>
<idno type="wicri:Area/Main/Merge">000588</idno>
<idno type="wicri:Area/Main/Curation">000588</idno>
<idno type="wicri:Area/Main/Exploration">000588</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Evaluation of Mild Cognitive Impairment Subtypes in Parkinson’s Disease</title>
<author><name sortKey="Cholerton, Brenna A" sort="Cholerton, Brenna A" uniqKey="Cholerton B" first="Brenna A." last="Cholerton">Brenna A. Cholerton</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Geriatric Research, Education, & Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Geriatric Research, Education, & Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A4">Department of Psychiatry & Behavioral Science, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry & Behavioral Science, Seattle, WA</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zabetian, Cyrus P" sort="Zabetian, Cyrus P" uniqKey="Zabetian C" first="Cyrus P." last="Zabetian">Cyrus P. Zabetian</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Geriatric Research, Education, & Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Geriatric Research, Education, & Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A2">Parkinson’s Disease Research, Education, & Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Parkinson’s Disease Research, Education, & Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A5">Department of Neurology, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Seattle, WA</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wan, Jia Y" sort="Wan, Jia Y" uniqKey="Wan J" first="Jia Y." last="Wan">Jia Y. Wan</name>
<affiliation wicri:level="2"><nlm:aff id="A6">Department of Epidemiology, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, Seattle, WA</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Montine, Thomas J" sort="Montine, Thomas J" uniqKey="Montine T" first="Thomas J." last="Montine">Thomas J. Montine</name>
<affiliation wicri:level="2"><nlm:aff id="A7">Department of Pathology University of Washington School of Medicine, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology University of Washington School of Medicine, Seattle, WA</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Quinn, Joseph F" sort="Quinn, Joseph F" uniqKey="Quinn J" first="Joseph F." last="Quinn">Joseph F. Quinn</name>
<affiliation wicri:level="2"><nlm:aff id="A8">Portland Veterans Affairs Medical Center, Portland, OR, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Portland Veterans Affairs Medical Center, Portland, OR</wicri:regionArea>
<placeName><region type="state">Oregon</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A9">Department of Neurology, Oregon Health and Science University, Portland, OR, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Oregon Health and Science University, Portland, OR</wicri:regionArea>
<placeName><region type="state">Oregon</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mata, Ignacio F" sort="Mata, Ignacio F" uniqKey="Mata I" first="Ignacio F." last="Mata">Ignacio F. Mata</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Geriatric Research, Education, & Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Geriatric Research, Education, & Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chung, Kathryn A" sort="Chung, Kathryn A" uniqKey="Chung K" first="Kathryn A." last="Chung">Kathryn A. Chung</name>
<affiliation wicri:level="2"><nlm:aff id="A8">Portland Veterans Affairs Medical Center, Portland, OR, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Portland Veterans Affairs Medical Center, Portland, OR</wicri:regionArea>
<placeName><region type="state">Oregon</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A9">Department of Neurology, Oregon Health and Science University, Portland, OR, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Oregon Health and Science University, Portland, OR</wicri:regionArea>
<placeName><region type="state">Oregon</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Peterson, Amie" sort="Peterson, Amie" uniqKey="Peterson A" first="Amie" last="Peterson">Amie Peterson</name>
<affiliation wicri:level="2"><nlm:aff id="A8">Portland Veterans Affairs Medical Center, Portland, OR, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Portland Veterans Affairs Medical Center, Portland, OR</wicri:regionArea>
<placeName><region type="state">Oregon</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A9">Department of Neurology, Oregon Health and Science University, Portland, OR, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Oregon Health and Science University, Portland, OR</wicri:regionArea>
<placeName><region type="state">Oregon</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Espay, Alberto J" sort="Espay, Alberto J" uniqKey="Espay A" first="Alberto J." last="Espay">Alberto J. Espay</name>
<affiliation wicri:level="2"><nlm:aff id="A10">Department of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, OH, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, OH</wicri:regionArea>
<placeName><region type="state">Ohio</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Revilla, Fredy J" sort="Revilla, Fredy J" uniqKey="Revilla F" first="Fredy J." last="Revilla">Fredy J. Revilla</name>
<affiliation wicri:level="2"><nlm:aff id="A10">Department of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, OH, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, OH</wicri:regionArea>
<placeName><region type="state">Ohio</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A11">Cincinnati Veteran Affairs Medical Center, Cincinnati, OH, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Cincinnati Veteran Affairs Medical Center, Cincinnati, OH</wicri:regionArea>
<placeName><region type="state">Ohio</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Devoto, Johnna" sort="Devoto, Johnna" uniqKey="Devoto J" first="Johnna" last="Devoto">Johnna Devoto</name>
<affiliation wicri:level="2"><nlm:aff id="A10">Department of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, OH, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, OH</wicri:regionArea>
<placeName><region type="state">Ohio</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Watson, G Stennis" sort="Watson, G Stennis" uniqKey="Watson G" first="G. Stennis" last="Watson">G. Stennis Watson</name>
<affiliation wicri:level="2"><nlm:aff id="A4">Department of Psychiatry & Behavioral Science, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry & Behavioral Science, Seattle, WA</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hu, Shu Ching" sort="Hu, Shu Ching" uniqKey="Hu S" first="Shu-Ching" last="Hu">Shu-Ching Hu</name>
<affiliation wicri:level="2"><nlm:aff id="A5">Department of Neurology, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Seattle, WA</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Leverenz, James B" sort="Leverenz, James B" uniqKey="Leverenz J" first="James B." last="Leverenz">James B. Leverenz</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Geriatric Research, Education, & Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Geriatric Research, Education, & Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A2">Parkinson’s Disease Research, Education, & Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Parkinson’s Disease Research, Education, & Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A3">Mental Illness Research, Education, & Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Mental Illness Research, Education, & Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A4">Department of Psychiatry & Behavioral Science, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry & Behavioral Science, Seattle, WA</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A5">Department of Neurology, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Seattle, WA</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Edwards, Karen L" sort="Edwards, Karen L" uniqKey="Edwards K" first="Karen L." last="Edwards">Karen L. Edwards</name>
<affiliation wicri:level="2"><nlm:aff id="A6">Department of Epidemiology, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, Seattle, WA</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Cross-Sectional Studies</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Mild Cognitive Impairment (diagnosis)</term>
<term>Mild Cognitive Impairment (etiology)</term>
<term>Neuropsychological Tests</term>
<term>Parkinson Disease (complications)</term>
<term>Principal Component Analysis</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Mild Cognitive Impairment</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Mild Cognitive Impairment</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Cross-Sectional Studies</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Neuropsychological Tests</term>
<term>Principal Component Analysis</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title>
<p id="P3">Mild cognitive impairment in Parkinson’s disease (PD-MCI) is common and increases the risk for dementia. Establishing distinct PD-MCI cognitive subtypes could be valuable for eventually predicting those most likely to convert to dementia. To date, however, the study of PD-MCI subtypes has not yielded consistent results among cohorts.</p>
</sec>
<sec id="S2"><title>Objective</title>
<p id="P4">To determine whether there are distinct cognitive subtypes among participants diagnosed with PD-MCI in the Pacific Northwest Udall Center Clinical Consortium.</p>
</sec>
<sec id="S3"><title>Methods</title>
<p id="P5">We cognitively subtyped 95 patients with PD-MCI using the Movement Disorders Society Task Force diagnostic guidelines. Psychometric test scores were then subjected to principle components factor analysis to determine whether similar cognitive subgroups could be identified using statistical methodology.</p>
</sec>
<sec id="S4"><title>Results</title>
<p id="P6">Multiple-domain PD-MCI was diagnosed in 95% of the sample, and a range of cognitive impairments were noted. Factor analysis yielded seven factors, and demonstrated overlap of phonemic verbal fluency on two factors, as well as the loading of verbal fluency on the same factor as a visuospatial measure; however, these factors did not partition the sample into distinct cognitive subtypes.</p>
</sec>
<sec id="S5"><title>Conclusions</title>
<p id="P7">Separation of cognitive subtypes based on the current PD-MCI criteria, or via statistical methods, may not provide sufficient information to describe distinct PD groups. Future efforts to validate the PD-MCI criteria and identify combinations of genetic or other risk factors for cognitive impairment are warranted.</p>
</sec>
</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Ohio</li>
<li>Oregon</li>
<li>Washington (État)</li>
</region>
</list>
<tree><country name="États-Unis"><region name="Washington (État)"><name sortKey="Cholerton, Brenna A" sort="Cholerton, Brenna A" uniqKey="Cholerton B" first="Brenna A." last="Cholerton">Brenna A. Cholerton</name>
</region>
<name sortKey="Cholerton, Brenna A" sort="Cholerton, Brenna A" uniqKey="Cholerton B" first="Brenna A." last="Cholerton">Brenna A. Cholerton</name>
<name sortKey="Chung, Kathryn A" sort="Chung, Kathryn A" uniqKey="Chung K" first="Kathryn A." last="Chung">Kathryn A. Chung</name>
<name sortKey="Chung, Kathryn A" sort="Chung, Kathryn A" uniqKey="Chung K" first="Kathryn A." last="Chung">Kathryn A. Chung</name>
<name sortKey="Devoto, Johnna" sort="Devoto, Johnna" uniqKey="Devoto J" first="Johnna" last="Devoto">Johnna Devoto</name>
<name sortKey="Edwards, Karen L" sort="Edwards, Karen L" uniqKey="Edwards K" first="Karen L." last="Edwards">Karen L. Edwards</name>
<name sortKey="Espay, Alberto J" sort="Espay, Alberto J" uniqKey="Espay A" first="Alberto J." last="Espay">Alberto J. Espay</name>
<name sortKey="Hu, Shu Ching" sort="Hu, Shu Ching" uniqKey="Hu S" first="Shu-Ching" last="Hu">Shu-Ching Hu</name>
<name sortKey="Leverenz, James B" sort="Leverenz, James B" uniqKey="Leverenz J" first="James B." last="Leverenz">James B. Leverenz</name>
<name sortKey="Leverenz, James B" sort="Leverenz, James B" uniqKey="Leverenz J" first="James B." last="Leverenz">James B. Leverenz</name>
<name sortKey="Leverenz, James B" sort="Leverenz, James B" uniqKey="Leverenz J" first="James B." last="Leverenz">James B. Leverenz</name>
<name sortKey="Leverenz, James B" sort="Leverenz, James B" uniqKey="Leverenz J" first="James B." last="Leverenz">James B. Leverenz</name>
<name sortKey="Leverenz, James B" sort="Leverenz, James B" uniqKey="Leverenz J" first="James B." last="Leverenz">James B. Leverenz</name>
<name sortKey="Mata, Ignacio F" sort="Mata, Ignacio F" uniqKey="Mata I" first="Ignacio F." last="Mata">Ignacio F. Mata</name>
<name sortKey="Montine, Thomas J" sort="Montine, Thomas J" uniqKey="Montine T" first="Thomas J." last="Montine">Thomas J. Montine</name>
<name sortKey="Peterson, Amie" sort="Peterson, Amie" uniqKey="Peterson A" first="Amie" last="Peterson">Amie Peterson</name>
<name sortKey="Peterson, Amie" sort="Peterson, Amie" uniqKey="Peterson A" first="Amie" last="Peterson">Amie Peterson</name>
<name sortKey="Quinn, Joseph F" sort="Quinn, Joseph F" uniqKey="Quinn J" first="Joseph F." last="Quinn">Joseph F. Quinn</name>
<name sortKey="Quinn, Joseph F" sort="Quinn, Joseph F" uniqKey="Quinn J" first="Joseph F." last="Quinn">Joseph F. Quinn</name>
<name sortKey="Revilla, Fredy J" sort="Revilla, Fredy J" uniqKey="Revilla F" first="Fredy J." last="Revilla">Fredy J. Revilla</name>
<name sortKey="Revilla, Fredy J" sort="Revilla, Fredy J" uniqKey="Revilla F" first="Fredy J." last="Revilla">Fredy J. Revilla</name>
<name sortKey="Wan, Jia Y" sort="Wan, Jia Y" uniqKey="Wan J" first="Jia Y." last="Wan">Jia Y. Wan</name>
<name sortKey="Watson, G Stennis" sort="Watson, G Stennis" uniqKey="Watson G" first="G. Stennis" last="Watson">G. Stennis Watson</name>
<name sortKey="Zabetian, Cyrus P" sort="Zabetian, Cyrus P" uniqKey="Zabetian C" first="Cyrus P." last="Zabetian">Cyrus P. Zabetian</name>
<name sortKey="Zabetian, Cyrus P" sort="Zabetian, Cyrus P" uniqKey="Zabetian C" first="Cyrus P." last="Zabetian">Cyrus P. Zabetian</name>
<name sortKey="Zabetian, Cyrus P" sort="Zabetian, Cyrus P" uniqKey="Zabetian C" first="Cyrus P." last="Zabetian">Cyrus P. Zabetian</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000588 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000588 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= MovDisordV3 |flux= Main |étape= Exploration |type= RBID |clé= PMC:4013249 |texte= Evaluation of Mild Cognitive Impairment Subtypes in Parkinson’s Disease }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:24710804" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a MovDisordV3
This area was generated with Dilib version V0.6.23. |